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ABT-199
CAS No. 1257044-40-8
ABT-199 ( GDC-0199 )
Catalog No. M11056 CAS No. 1257044-40-8
Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 75 | In Stock |
|
| 50MG | 80 | In Stock |
|
| 100MG | 104 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameABT-199
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NoteResearch use only, not for human use.
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Brief DescriptionVenetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays.
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DescriptionVenetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 3.
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SynonymsGDC-0199
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PathwayAngiogenesis
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TargetBcl-2
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RecptorMcl-1; Bcl-2; Bcl-w; Bcl-xL
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1257044-40-8
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Formula Weight868.44
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Molecular FormulaC45H50ClN7O7S
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Purity>98%(HPLC)
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SolubilityDMSO: 100 mg/mL warmed (115.14 mM)
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SMILESO=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
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Chemical Name4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Souers AJ, et al. Nat Med, 2013, 19(2), 202-208.
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